Browsing by Author "Anakri, Yasendi"

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    SINTESIS DAN STUDI IN SILICO SENYAWA PIRAZOLIN 2-(5-(3- BROMOFENIL)-1-FENIL-4,5-DIHIDRO-1H-PIRAZOL-3- IL)NAFTALEN-1-OL) SEBAGAI KANDIDAT ANTIKANKER PAYUDARA
    (Elfitra, 2023-09) Anakri, Yasendi; Jasril, Jasril
    Pyrazoline is a secondary metabolic compound containing five circular heterocyclic structures, comprising three carbon atoms and two nitrogen atoms positioned closely to each other. Due to its high toxicity, Pyrazoline exhibits diverse bioactivities, including antitumor and anticancer properties. Pyrazoline (2-(5-3-bromophenyl)-1-phenyl-4,5- dihydro-1H-pyrazole-3-yl)naphtalene-1-ol) has been successfully synthesized through several phases of reaction. The first phase involves the formation of chalcone 3-(3- bromophenyl)-1-(1-hydroxynaphthalene-2-yl)-2-propen-1-one by reacting the compound 1-hydroxy-2-acetylnaphthalene with 3-bromobenzaldehyde using the microwave irradiation method. Chalcone was synthesized using Claisen-Schmidt condensation reactions, resulting in a yield of 85.86%. In the subsequent step, chalcone was reacted with phenylhydrazine, leading to the desired compound in the presence of a sodium hydroxide catalyst. The synthesis of the target compound employed stirring and heating with seal tube, yielding 40.18%. The purification of the Pyrazoline compound was achieved through recrystallization. Its purity was assessed using TLC test, melting point determination, and HPLC analysis. Furthermore, the confirmation of its structure was based on spectroscopic data from UV, FTIR and LCMS. The molecular docking of PF-NH1-3Br against Estrogen α receptors revealed a free bond energy (ΔGbind) of -9,5 kcal/mol.