Browsing by Author "Kurniati, Maya"

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    SINTESIS SENYAWA 4-(1-(4-FLUOROFENIL)-5-(3-METOKSIFENIL)- 4,5-DIHIDRO-1H-PIRAZOL-3-IL) FENOL
    (Elfitra, 2024-01) Kurniati, Maya; Jasril, Jasril
    Pyrazoline has two nitrogen atoms adjacent to each other in its ring and possess only one endocyclic double bond. The pyrazoline compound 4-(1-(4-Fluorophenyl)-5-(3- Methoxyphenyl)-4,5-Dihydro-1H-Pirazol-3-yl) phenol and named as P3OME-4OH-4F has been successfully synthesized through three stages reaction. The first stage is the formation of the chalcone compound through the Claisen-Schmidt condensation reaction with a yield of 54%, the second stage is the formation of the hydrazine compound through diazotation and reduction reactions with a yield of 84% and the final stage is the formation of the P3OME-4OH-4F compound through a cyclization reaction with a yield obtained of 52%. The purity of the compound was tested by measuring the melting point, TLC and HPLC analysis. The structure of the P3OME-4OH-4F compound was confirmed by characterization using UV spectroscopy and FTIR.