Browsing by Author "Putri, Sofia Rahmawati"

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    SINTESIS DAN UJI TOKSISITAS PIRAZOLIN 5-(4-METOKSIFENIL)-3-(NAFTALEN-2-IL)-N-FENIL -4,5-DIHIDRO-1H-PIRAZOL-1-KARBOTIAMIDA
    (Elfitra, 2022-11) Putri, Sofia Rahmawati; Jasril, Jasril
    Pyrazoline is heterocycles compound that has various biological activities such as anticancer. Pyrazoline 5-(4-methoxyphenyl)-3-(naphthalen-2-yl)-N-phenyl-4,5-dihydro- 1H-pyrazole-1-carbothioamide (PR-2NFT-4FTS) had successfully synthesized by the formation of chalcone 3-(4-methoxyphenyl)-1-(naphthalen-2-yl)-2-propen-1-one by reacting 2-acetylnaphthalene compound with 4-methoxybenzaldehide. Chalcone was reacted with 4-phenilthiosemicarbazide to produce target compound used hydrochloric acid as catalyst. The purity of the compound was determined using TLC, melting point, and HPLC. The structure of synthesized compound was confirmed by ultraviolet (UV) and fourier transform infra-red (FTIR) spectroscopy data analysis. The yield of the synthesis PR-2NFT-4FTS compound was 35.97%. The toxicity of PR-2NFT-4FTS compound was evaluated by brine shrimp lethality test (BSLT) method with shrimp larvae Artemia salina Leach. The result of the test showed PR-2NFT-4FTS compound is not toxic with LC50 > 1000 μg/mL.