Browsing by Author "Syafitri, Bella"

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    SINTESIS PIRAZOLIN 5- (2-BROMOFENIL)-3-(1- HIDROKSINAFTALEN-2-IL)-1- FENIL-4,5-DIHIDRO-1H-PIRAZOL
    (Elfitra, 2023-12) Syafitri, Bella; Jasril
    Pyrazoline is five ring heterocyclic compounds with two adjacent nitrogen atoms which is known to have diverse biological activities such as antioxidant, antitumor and anticancer agent. The synthesis of pyrazoline (5-(2- bromophenyl)-3-(1- hydroxynaphthalene-2-yl)-1-phenyl-4,5-dihydro-1H-pyrazole begins with the formation of chalcone by reacting 1-hydroxy-2-acetyl naphthalene with 2-bromobenzaldehide using microwave irradiation method. The next step was reacted chalcone with phenyl hydrazine to produce target compound used sodium hydroxide catalyst with a monowave for 3 hours at a temperature of 80℃ and the resulting yield was 72%. The purity of the target compound was determined using TLC, melting point and HPLC. Analysis and confirming structure based on spectroscopic data of UV and FTIR.