Browsing by Author "Yulia, Sisi"

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    SINTESIS DAN UJI TOKSISITAS (2E,2'E)-3,3'-(1,4-FENILEN)BIS(1-(3- METOKSIFENIL)PROP-2-EN-1-ON
    (2020-05) Yulia, Sisi; Eryanti, Yum
    Chalcone is one of the secondary metabolites of the flavonoid group that has two aromatic rings connected by three carbon α, β unsaturated, the distribution of chalcone compounds in nature is very limited but has many important biological activities. In this research, symmetric chalcone (2E, 2'E) -3.3'- (1,4-phenylene) bis (1- (3-methoxyphenyl) prop-2-en-1-on chalcone was carried out and toxicity testing of these compounds. Chalcone compound was synthesized from the aldol condensation reaction between 3-methoxyacetophenone and terepthaldialdeid which was catalyzed by the NaOH base using stirring at 0-5 0C. The purity of the coumpounds was determined using by KLT test, melting point and HPLC analysis. Compounds structure was analyzed using UV spectroscopy, FTIR, 1H-NMR, and HRMS. The yield obtained from the synthesis is 31,25 %. Compounds toxicity test K1-3OMe determined by the BSLT method using shrimp larvae (Arthemia Salina Leach). LC50 value of compounds K1-3OMe is 216,27μg/mL. Concluded that the compound K1-3OMe are not toxic.