SINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-KLOROFENIL)-3- (NAFTALEN-2-IL)-1-FENIL-1H-PIRAZOL DARI PIRAZOLIN
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Date
2020-08
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Abstract
Pyrazole is a 5-ring heterocyclic compound which consist of 3 carbon atoms and 2
neighboring nitrogen atoms. This study was aimed to synthetized pyrazol compound
and toxicity of the compound was determined by BSLT method. The pyrazole 5-(4-
chlorophenyl)-3-(naphthalene-2-il)-phenyl-1H-pyrazole was synthesized through the
oxidative aromatization reaction of pyrazolin compounds with glacial acetic acid. The
synthesized compound was tested for purity using TLC, melting point and HPLC
analysis. The structure of the synthesized compound was confirmed through UV
spectroscopy and FTIR. The synthesis of pyrazole has the yield of 38,3%. Pyrazole was
subjected to toxicity test through BSLT method using shrimp larvae (Artemia salina
Leach). The pyrazole was toxic with LC50 value of 20,13 μg/mL.
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Keywords
aromatization, pyrazole, synthesis