SINTESIS DAN UJI TOKSISITAS (2E,2'E)-3,3'-(1,4-FENILEN)BIS(1-(3- METOKSIFENIL)PROP-2-EN-1-ON
| dc.contributor.author | Yulia, Sisi | |
| dc.contributor.supervisor | Eryanti, Yum | |
| dc.date.accessioned | 2021-06-17T08:01:06Z | |
| dc.date.available | 2021-06-17T08:01:06Z | |
| dc.date.issued | 2020-05 | |
| dc.description.abstract | Chalcone is one of the secondary metabolites of the flavonoid group that has two aromatic rings connected by three carbon α, β unsaturated, the distribution of chalcone compounds in nature is very limited but has many important biological activities. In this research, symmetric chalcone (2E, 2'E) -3.3'- (1,4-phenylene) bis (1- (3-methoxyphenyl) prop-2-en-1-on chalcone was carried out and toxicity testing of these compounds. Chalcone compound was synthesized from the aldol condensation reaction between 3-methoxyacetophenone and terepthaldialdeid which was catalyzed by the NaOH base using stirring at 0-5 0C. The purity of the coumpounds was determined using by KLT test, melting point and HPLC analysis. Compounds structure was analyzed using UV spectroscopy, FTIR, 1H-NMR, and HRMS. The yield obtained from the synthesis is 31,25 %. Compounds toxicity test K1-3OMe determined by the BSLT method using shrimp larvae (Arthemia Salina Leach). LC50 value of compounds K1-3OMe is 216,27μg/mL. Concluded that the compound K1-3OMe are not toxic. | en_US |
| dc.description.sponsorship | Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riau Kampus Binawidya, Pekanbaru, 28293, Indonesia *sisi.yulia2803@student.unri.ac.id | en_US |
| dc.identifier.other | wahyu sari yeni | |
| dc.identifier.uri | https://repository.unri.ac.id/handle/123456789/9989 | |
| dc.language.iso | en | en_US |
| dc.subject | chalcone | en_US |
| dc.subject | flavonoid | en_US |
| dc.subject | toxicity | en_US |
| dc.title | SINTESIS DAN UJI TOKSISITAS (2E,2'E)-3,3'-(1,4-FENILEN)BIS(1-(3- METOKSIFENIL)PROP-2-EN-1-ON | en_US |
| dc.type | Article | en_US |